Majeed S K
Huntingdon Research Centre, Pathology Department, Cambridgeshire, UK.
Arzneimittelforschung. 1994 Mar;44(3):370-4.
A survey on the distribution of mast cells in healthy rats was carried out. Mast cells were present in abundance in mesenteric lymph nodes and tongue and to a lesser extent in sciatic nerve. Fewer numbers of mast cells were seen in other lymph nodes, heart, salivary gland, thymus, pancreas, cervix, vagina, uterus, epididymis, liver, skeletal muscle, ovaries, prostate, seminal vesicles, harderian glands, parathyroid, thyroid, mammary gland, skin, adipose tissue, preputial gland, tail and bone marrow. Scattered individual mast cells were occasionally seen in submucosa and serosa of stomach, oesophagus, small and large intestine and urinary bladder. Mast cells were very rare in lung, spleen and adrenals. Mast cells were not seen in kidney, pituitary, testes, bone spinal cord, brain, optic nerves and eyes. In lymph nodes, mast cells appeared mainly in medullary sinusoids with varying extent. There was no clear evidence of a difference between numbers of mast cells in young and older animals. There was evidence of increased numbers of mast cells in inflammatory lesions, of skin and heart. Mast cells were seen associated with mammary tumours, fibromas and fibrosarcomas. There were more mast cells in rats than in mice. Mast cells appear to be more abundant in Wistar rats than in CD rats. Mast cells were hardly seen in healthy dogs and primates except a few in tongue and sciatic nerve. Presence of mast cells is incidental and not indicative of any abnormalities.
对健康大鼠体内肥大细胞的分布进行了一项调查。肥大细胞大量存在于肠系膜淋巴结和舌头中，坐骨神经中的数量较少。在其他淋巴结、心脏、唾液腺、胸腺、胰腺、子宫颈、阴道、子宫、附睾、肝脏、骨骼肌、卵巢、前列腺、精囊、哈德氏腺、甲状旁腺、甲状腺、乳腺、皮肤、脂肪组织、包皮腺、尾巴和骨髓中，肥大细胞数量较少。在胃、食管、小肠、大肠和膀胱的黏膜下层和浆膜层偶尔可见散在的单个肥大细胞。肥大细胞在肺、脾和肾上腺中非常罕见。在肾脏、垂体、睾丸、脊髓、脑、视神经和眼睛中未发现肥大细胞。在淋巴结中，肥大细胞主要出现在髓窦中，程度各异。没有明确证据表明年轻动物和老年动物的肥大细胞数量存在差异。有证据表明，皮肤和心脏的炎症病变中肥大细胞数量增加。在乳腺肿瘤、纤维瘤和纤维肉瘤中可见肥大细胞。大鼠体内的肥大细胞比小鼠多。Wistar大鼠体内的肥大细胞似乎比CD大鼠更多。除了舌头和坐骨神经中有少数肥大细胞外，在健康的狗和灵长类动物中几乎看不到肥大细胞。肥大细胞的存在是偶然的，并不表明有任何异常。
