Chiariello M, Ambrosio G
Division of Cardiology, Federico II School of Medicine, Naples, Italy.
Rev Port Cardiol. 1994 Sep;13(9):655-9.
Large quantities of oxygen free radicals can be generated on reperfusion of the ischemic myocardium. This phenomenon is probably responsible for a specific component of cell damage separate from ischemic injury and may blunt the beneficial effects of thrombolysis. Anti-free radical interventions may reduce the severity of this "reperfusion injury". However, reports of treatment failures indicate that reperfusion injury is a complex phenomenon, and suggest that the beneficial effects of treatment may be critically dependent on factors that are not clearly understood.
在缺血心肌再灌注时可产生大量氧自由基。这种现象可能是造成与缺血性损伤不同的一种特定细胞损伤成分的原因，并且可能会削弱溶栓的有益效果。抗自由基干预措施可能会减轻这种“再灌注损伤”的严重程度。然而，关于治疗失败的报告表明，再灌注损伤是一种复杂的现象，这表明治疗的有益效果可能严重依赖于一些尚未完全清楚的因素。
