Maung Z T, Wood A C, Jackson G H, Turner G E, Appleton A L, Hamilton P J
Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne.
Br J Haematol. 1994 Nov;88(3):649-52. doi: 10.1111/j.1365-2141.1994.tb05093.x.
Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare but serious complication of blood component therapy in patients with haematological malignancies. B-chronic lymphocytic leukaemia (B-CLL), however, has rarely been associated with TA-GVHD. We report three patients with advanced B-CLL who developed TA-GVHD. All these had been treated with fludarabine. Suppression of T cells by fludarabine may have contributed to an increased susceptibility to TA-GVHD. The use of irradiated blood products to prevent this complication should be considered for patients with advanced B-CLL treated with fludarabine or other purine analogues.
输血相关移植物抗宿主病（TA-GVHD）是血液系统恶性肿瘤患者接受血液成分治疗时罕见但严重的并发症。然而，B细胞慢性淋巴细胞白血病（B-CLL）很少与TA-GVHD相关。我们报告了3例进展期B-CLL患者发生TA-GVHD的情况。所有这些患者均接受过氟达拉滨治疗。氟达拉滨对T细胞的抑制作用可能导致了对TA-GVHD易感性增加。对于接受氟达拉滨或其他嘌呤类似物治疗的进展期B-CLL患者，应考虑使用辐照血液制品以预防这一并发症。
