胰高血糖素产生的小胰高血糖素：一种用作激素原的激素的细胞外加工过程。
Miniglucagon production from glucagon: an extracellular processing of a hormone used as a prohormone.
作者信息
Blache P, Kervran A, Le-Nguyen D, Bataille D
机构信息
INSERM U 376, CCIPE, Montpellier, France.
出版信息
Biochimie. 1994;76(3-4):295-9. doi: 10.1016/0300-9084(94)90161-9.
PMID:7819338
Abstract
Glucagon is secondarily processed into its C-terminal (19-29) fragment, referred to as 'miniglucagon', which modulates the glucagon action. This extracellular processing, occurring at the level of of the glucagon target cells, is due to the presence at the cell surface of a new 100-kDa processing enzyme with characteristics of both thiol- and metalloprotease.
摘要
胰高血糖素会进一步加工成其C端（19 - 29）片段，即所谓的“迷你胰高血糖素”，它可调节胰高血糖素的作用。这种在胰高血糖素靶细胞水平发生的细胞外加工过程，是由于细胞表面存在一种新的100 kDa加工酶，该酶具有巯基蛋白酶和金属蛋白酶的特性。
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