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[非洲黑人高流行区城市地区的恶性疟原虫疟疾。潜在严重性及可能的预防措施]

[Plasmodium falciparum malaria in urban zones of high endemic regions in black Africa. Potential seriousness and possible preventive measures].

作者信息

Carme B

机构信息

Service de Parasitologie-Mycologie, Faculté et CHU d'Amiens, France.

出版信息

Bull Soc Pathol Exot. 1993;86(5 Pt 2):394-8.

PMID:7819787
Abstract

By the year 2000, 40% of the population of sub-Saharan Africa (western and middle Africa) will live in urban areas. It is obvious that urbanization reduces the transmission of malaria and make treatment easier. However, excessive optimism is inappropriate in regions where malaria transmission remains intense and where it is unfortunately illusory to hope for any major or geographically extensive reduction in transmission outside urban and suburban areas. In this context, the benefit of a reduction in malarial morbidity could be compromised by the increased risk of severe forms in town-dwellers, who now have little or no immunity, when they venture into the surrounding rural zone. The prevention of malaria during trips to endemic areas has become a reality for sub-Saharan African town-dwellers. We have to conceive and propose specific protective measures. This version of the advice to travellers about malaria, intended for use in Africa, is fairly similar, in theory, to the advice we give in Europe to travellers going to tropical areas: 1) at most, chemoprophylaxis throughout the exposure period plus 2 or 4 weeks after their return; 2) in all cases, protection against anopheles (take and travel with an impregnated mosquito net) and: 3) above all, the systematic and rapid treatment of any suspected attack of malaria (take and travel with a medicine pack containing antimalarials). If it seems vain to hope to be able to apply these measures in the current socio-economic situation in sub-Saharan African, they are nonetheless justified.

摘要

到2000年,撒哈拉以南非洲地区(西非和中非)40%的人口将居住在城市地区。显然,城市化会减少疟疾传播并使治疗更加容易。然而,在疟疾传播仍然严重的地区,过度乐观是不合适的,而且希望在城市和郊区以外地区大幅或广泛减少疟疾传播是不切实际的幻想。在这种情况下,城市居民前往周边农村地区时,由于几乎没有或完全没有免疫力,严重疟疾的发病风险增加,这可能会抵消疟疾发病率下降带来的益处。对于撒哈拉以南非洲的城市居民来说,在前往疟疾流行地区旅行期间预防疟疾已成为现实。我们必须构思并提出具体的保护措施。这个针对非洲旅行者的疟疾防治建议版本,理论上与我们在欧洲给前往热带地区旅行者的建议相当相似:1)最多在整个暴露期以及返回后2至4周内进行化学预防;2)在所有情况下,防止被按蚊叮咬(携带并使用浸药蚊帐);3)最重要的是,对任何疑似疟疾发作进行系统、快速的治疗(携带并使用装有抗疟药的药包)。如果在撒哈拉以南非洲目前的社会经济状况下,希望实施这些措施似乎是徒劳的,但它们仍然是合理的。

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