Burthem J, Cawley J C
Department of Haematology, University of Liverpool, UK.
Leuk Lymphoma. 1994;14 Suppl 1:19-22.
HCs have a distinctive profile of matrix-binding integrin receptors which partly reflects their activated nature. HCs show differing functional responses to individual adhesive proteins, and these are mediated by particular integrin heterodimers. In particular, HCs are motile on Vitronectin (VN), and this motility is mediated by alpha v beta 3. HCs are immobile but actively spread on Fibronectin (FN) and this response is mediated by beta 1 integrins. M-CSF enhances the mobility (chemotaxis and chemokinesis) of HCs, and this response is partly mediated by alpha v beta 3. HCs synthesise and assemble fibronectin and this is, at least partly, the cause of the distinctive bone marrow fibrosis of hairy-cell leukaemia.
毛细胞（HCs）具有独特的基质结合整合素受体谱，这在一定程度上反映了它们的活化性质。毛细胞对单个粘附蛋白表现出不同的功能反应，这些反应由特定的整合素异二聚体介导。特别是，毛细胞在玻连蛋白（VN）上具有运动性，这种运动性由αvβ3介导。毛细胞在纤连蛋白（FN）上不运动但能积极铺展，这种反应由β1整合素介导。巨噬细胞集落刺激因子（M-CSF）增强毛细胞的迁移能力（趋化性和化学运动性），这种反应至少部分由αvβ3介导。毛细胞合成并组装纤连蛋白，这至少部分是毛细胞白血病独特的骨髓纤维化的原因。
