Burthem J, Vincent A, Cawley J C
University Department of Haematology, Royal Liverpool University Hospital, U.K.
Leuk Lymphoma. 1996 Apr;21(3-4):211-5. doi: 10.3109/10428199209067602.
The ability of a cell to recognize and specifically localise within an appropriate tissue environment is essential to the proliferation and survival of that cell. The integrin family of cell-surface adhesion-receptors are essential to such tissue localisation, allowing a migrating cell to specifically recognise, localise within-, and respond to- the cellular or extracellular matrix ligands that characterise a given tissue. We have investigated how the expression and activity of integrin receptors underlies the consistent and unusual tissue distribution of the malignant B lymphocytes of hairy cell leukaemia (HCL). In this report we review our published work in this area. Our findings are then discussed within the context of current knowledge of integrin receptors and their ligands, and in relation to the clinical features of HCL.
细胞识别并特异性定位于合适组织环境的能力对于该细胞的增殖和存活至关重要。细胞表面黏附受体的整合素家族对于这种组织定位至关重要，它使迁移的细胞能够特异性识别、定位于并响应特定组织所特有的细胞或细胞外基质配体。我们研究了整合素受体的表达和活性如何构成毛细胞白血病（HCL）恶性B淋巴细胞一致且异常的组织分布基础。在本报告中，我们回顾了我们在该领域已发表的工作。然后，我们将在整合素受体及其配体的现有知识背景下，并结合HCL的临床特征来讨论我们的发现。
