Hertel E, Bartels J
Z Rheumatol. 1976 May-Jun;35(5-6):195-200.
With a modified Coons technique synovial tissue, anti human IgG, IgA, IgM, anti-coeruloplasmine, anti-transferrin, and anti-fibrin were investigated by means of immunofluorescence and evaluated with reference to place, type, and intensity of fluorescence. It was shown that fibrin deposits in the synovial tissue in rheumatoid synovitis do not only consist of the actual fibrin but often of immune complexes. These were mainly found near vessels and necroses, whereas unspecific fibrin was detected mainly in fibers and limiting areas. Coeruloplasmine and transferrin seem to have a marked affinity to pathogenetically changed fibers, whereas they do not combine with normal fibers. In seropositive RA remarkable immuno fluorescence was observed in vessels. From these facts certain etiological conclusions on rheumatoid diseases can be drawn.
采用改良的孔斯技术，通过免疫荧光法研究了滑膜组织、抗人IgG、IgA、IgM、抗铜蓝蛋白、抗转铁蛋白和抗纤维蛋白，并根据荧光的位置、类型和强度进行了评估。结果表明，类风湿性滑膜炎滑膜组织中的纤维蛋白沉积物不仅由实际的纤维蛋白组成，还常常由免疫复合物组成。这些主要在血管和坏死灶附近发现，而非特异性纤维蛋白主要在纤维和边界区域检测到。铜蓝蛋白和转铁蛋白似乎对病变纤维有明显的亲和力，而它们不与正常纤维结合。在血清阳性类风湿性关节炎中，血管内观察到显著的免疫荧光。从这些事实中可以得出关于类风湿性疾病的某些病因学结论。
