Simonsen L, Bülow J, Tuxen C, Christensen N J
Department of Clinical Physiology/Nuclear Medicine Hvidovre Hospital, Denmark.
Clin Physiol. 1994 Sep;14(5):489-99. doi: 10.1111/j.1475-097x.1994.tb00408.x.
Seven patients with histologically verified small cell lung carcinoma were given an oral glucose load of 75 g on two occasions to examine the effect of glucose on whole body and forearm thermogenesis with and without acute beta-adrenergic inhibition with propranolol. Whole body energy expenditure was measured by the open circuit ventilated hood system. Forearm blood flow was measured by venous occlusion strain-gauge plethysmography. The uptake of oxygen in the forearm was calculated as the product of the forearm blood flow and the difference in arteriovenous oxygen concentration. The glucose-induced thermogenesis in the 120 min following the glucose load was significantly reduced by beta-adrenergic inhibition with approximately 50% from 63.9 +/- 5.8 kJ 120 min-1 (mean +/- SE) to 27.8 +/- 9.8 kJ 120 min-1 (P < 0.01). Almost the entire reduction took place from 60 to 120 min (P < 0.005). The integrated glucose-induced forearm oxygen uptake in the period 60-120 min following the glucose load was significantly reduced after beta-adrenergic inhibition from 103 +/- 28 mumol 100 g-1 60 min-1 to 29 +/- 29 mumol 100 g-1 60 min-1 (P < 0.05). The noreadrenaline concentration in the arterial blood was not increased in the baseline period compared to healthy elderly; it increased following the glucose load while there was no demonstrable increase in adrenaline concentration in the two experiments. It is suggested that these patients have increased sensitivity of the beta-adrenergic receptors and an early facultative component of the glucose-induced thermogenesis in part takes place in the forearm.
七名经组织学证实为小细胞肺癌的患者，在两种情况下分别接受了75克口服葡萄糖负荷，以研究葡萄糖对全身和前臂产热的影响，同时观察有无普萘洛尔对β-肾上腺素能的急性抑制作用。全身能量消耗通过开路通风面罩系统测量。前臂血流量通过静脉阻断应变片体积描记法测量。前臂的氧摄取量通过前臂血流量与动静脉氧浓度差的乘积计算得出。葡萄糖负荷后120分钟内，β-肾上腺素能抑制使葡萄糖诱导的产热显著降低，从63.9±5.8千焦/120分钟（平均值±标准误）降至27.8±9.8千焦/120分钟，降低了约50%（P<0.01）。几乎整个降低过程发生在60至120分钟（P<0.005）。葡萄糖负荷后60至120分钟期间，β-肾上腺素能抑制后，葡萄糖诱导的前臂氧摄取量积分显著降低，从103±28微摩尔/100克/60分钟降至29±29微摩尔/100克/60分钟（P<0.05）。与健康老年人相比，在基线期动脉血中去甲肾上腺素浓度没有升高；葡萄糖负荷后其浓度升高，而在这两个实验中肾上腺素浓度没有明显升高。提示这些患者的β-肾上腺素能受体敏感性增加，且葡萄糖诱导产热的早期适应性成分部分发生在前臂。
