Brundin T, Aksnes A K, Wahren J
Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden.
Am J Physiol. 1997 Apr;272(4 Pt 1):E678-87. doi: 10.1152/ajpendo.1997.272.4.E678.
The aim of the study was to assess the possible contribution of adrenergic mechanisms to the thermogenic and circulatory effects of glucose ingestion. With the use of indirect calorimetry and arterial, pulmonary arterial, and hepatic venous catheterization, whole body and splanchnic oxygen uptake and blood flow were examined in nine propranolol-treated healthy male volunteers before and during 2 h after oral ingestion of 75 g of glucose. The glucose effects were compared with those in nine untreated controls. After propranolol, the glucose-induced rise in splanchnic blood flow was reduced by approximately 60%, and the hepatic venous glucose release to the systemic circulation was significantly delayed. Glucose-induced increments in pulmonary and splanchnic oxygen uptake and cardiac output were similar in the two groups. It is concluded that adrenergic mechanisms contribute to the glucose-induced rise in splanchnic blood flow and thereby probably to the time course for intestinal absorption of nutrients. It is suggested that the magnitude of glucose-induced thermogenesis is independent of adrenergic stimulation.
本研究的目的是评估肾上腺素能机制对葡萄糖摄入所产生的产热和循环效应可能的作用。通过使用间接测热法以及动脉、肺动脉和肝静脉插管，在9名接受普萘洛尔治疗的健康男性志愿者口服75克葡萄糖之前及之后2小时内，检测了全身和内脏的氧摄取及血流量。将葡萄糖效应与9名未接受治疗的对照者的效应进行了比较。使用普萘洛尔后，葡萄糖诱导的内脏血流量增加减少了约60%，肝静脉葡萄糖释放到体循环明显延迟。两组中葡萄糖诱导的肺和内脏氧摄取及心输出量的增加相似。得出的结论是，肾上腺素能机制促成了葡萄糖诱导的内脏血流量增加，从而可能影响营养物质在肠道吸收的时间进程。提示葡萄糖诱导的产热幅度与肾上腺素能刺激无关。
