Mazzella M, Cotellessa M, Bonassi S, Mulas R, Caratozzolo A, Gaber S, Romano C
University Department of Pediatrics, G. Gaslini Scientific Institute, Genoa, Italy.
Diabetes Care. 1994 Oct;17(10):1193-6. doi: 10.2337/diacare.17.10.1193.
To assess updated incidence of insulin-dependent diabetes mellitus (IDDM) in 0- to 14-year-old children in Liguria, a northwest region of Italy.
Incident cases were recorded prospectively from 1987 to 1991. Incidence rates (IRs) were directly standardized on the basis of the 1990 world population. The independent effect of age, sex, residence, and calendar year was estimated with a Poisson regression model. The degree of ascertainment was calculated in accordance with the capture/recapture method.
During 5 full calendar years, 117 new cases of IDDM in children were diagnosed in Liguria. The standardized IR over the 5-year period was 11.72 cases.100,000(-1).year-1. The sex-specific IR among males and females was 11.45 and 12.01, respectively. The age-specific IR was higher in the 5-9 age-group.
The IR of IDDM in Liguria is among the highest in southern Europe and approaches that of northern European countries. In particular, it is much higher than those reported in the surrounding Italian regions, except for Sardinia. Therefore, the geographical distribution of IDDM does not seem to reflect the simple north-south gradient reported in several previous studies.
评估意大利西北部利古里亚地区0至14岁儿童胰岛素依赖型糖尿病（IDDM）的最新发病率。
前瞻性记录1987年至1991年的发病病例。发病率（IR）根据1990年世界人口直接标准化。采用泊松回归模型估计年龄、性别、居住地和日历年的独立影响。根据捕获/再捕获方法计算确定程度。
在整整5个日历年中，利古里亚地区诊断出117例儿童IDDM新病例。5年期间的标准化发病率为11.72例/100,000（-1）·年-1。男性和女性的性别特异性发病率分别为11.45和12.01。5至9岁年龄组的年龄特异性发病率较高。
利古里亚地区IDDM的发病率在南欧最高，接近北欧国家。特别是，除撒丁岛外，它远高于意大利周边地区报告的发病率。因此，IDDM的地理分布似乎并不反映先前几项研究中报道的简单南北梯度。
