Pujia A, Gnasso A, Irace C, Colonna A, Mattioli P L
Department of Experimental and Clinical Medicine, Medical School of Catanzaro, Italy.
Diabetes Care. 1994 Nov;17(11):1330-6. doi: 10.2337/diacare.17.11.1330.
To verify whether carotid arterial intimal plus media thickness (IMT) is greater in non-insulin-dependent diabetes mellitus (NIDDM) subjects, known to be at high risk for atherosclerosis. Evidence is growing that IMT is increased in subjects with coronary heart disease (CHD) risk factors like hypercholesterolemia and cigarette smoking.
Fifty-four NIDDM subjects and 54 sex- and age-matched control subjects underwent CHD risk factors assessment and echo-Doppler examination of carotid arteries. IMT was measured by computer technique in the common carotid artery (CCA). Presence of plaques and/or stenosis (carotid atherosclerosis [CA]) was also evaluated by a single-blinded reader.
NIDDM subjects had larger IMT, higher levels of triglycerides, and lower concentrations of high-density lipoprotein (HDL) cholesterol compared with control subjects. IMT was positively correlated to age and systolic blood pressure and inversely to HDL cholesterol in both groups. The prevalence of CA was 46% in NIDDM subjects and 18% in control subjects. In multiple regression analysis, IMT was the only variable significantly associated to CA.
IMT of CCA is enlarged in NIDDM subjects compared with control subjects. Its association with carotid plaques and/or stenosis might be of importance to detect early atherosclerotic lesions in the carotid arteries.
已知非胰岛素依赖型糖尿病（NIDDM）患者具有较高的动脉粥样硬化风险，本研究旨在验证此类患者的颈动脉内膜加中膜厚度（IMT）是否更大。越来越多的证据表明，具有高胆固醇血症和吸烟等冠心病（CHD）危险因素的患者IMT会增加。
54例NIDDM患者和54例年龄及性别匹配的对照者接受了CHD危险因素评估和颈动脉超声多普勒检查。通过计算机技术测量颈总动脉（CCA）的IMT。由一名单盲观察者评估斑块和/或狭窄（颈动脉粥样硬化[CA]）的存在情况。
与对照者相比，NIDDM患者的IMT更大，甘油三酯水平更高，高密度脂蛋白（HDL）胆固醇浓度更低。两组中，IMT均与年龄和收缩压呈正相关，与HDL胆固醇呈负相关。NIDDM患者中CA的患病率为46%，对照者中为18%。在多元回归分析中，IMT是与CA显著相关的唯一变量。
与对照者相比，NIDDM患者的CCA的IMT增大。其与颈动脉斑块和/或狭窄的关联可能对检测颈动脉早期动脉粥样硬化病变具有重要意义。
