Kline L W, Pang P K
Department of Oral Biology, University of Alberta, Edmonton, Canada.
Gen Comp Endocrinol. 1994 Sep;95(3):381-6. doi: 10.1006/gcen.1994.1137.
The presence of a calcitonin gene-related peptide (CGRP)-like material was demonstrated in the iguana, Iguana iguana, gallbladder using immunocytochemistry. An intense reaction was observed in nerves located in the smooth muscle layers and associated blood vessels but no immunoreactive cell bodies were found. In vitro tension studies using gallbladder strips showed that chicken CGRP was more potent in relaxing cholecystokinin-induced tension than either human or rat CGRP. The use of glibenclamide and L-NG-nitro-arginine methyl ester suggested that this relaxation is mediated by either nitric oxide release from nerves stimulated by CGRP or by CGRP acting directly on the gallbladder smooth muscle.
利用免疫细胞化学方法在绿鬣蜥（Iguana iguana）的胆囊中证实了降钙素基因相关肽（CGRP）样物质的存在。在位于平滑肌层和相关血管的神经中观察到强烈反应，但未发现免疫反应性细胞体。使用胆囊条进行的体外张力研究表明，鸡CGRP在舒张胆囊收缩素诱导的张力方面比人或大鼠CGRP更有效。使用格列本脲和L-NG-硝基精氨酸甲酯表明，这种舒张作用是由CGRP刺激神经释放一氧化氮介导的，或者是由CGRP直接作用于胆囊平滑肌介导的。
