Kirschner C V, Yordan E L, De Geest K, Wilbanks G D
Department of Obstetrics and Gynecology, Rush Medical College, Chicago, Illinois 60612.
Gynecol Oncol. 1995 Jan;56(1):79-84. doi: 10.1006/gyno.1995.1013.
One hundred thirty-six patients with invasive squamous cell carcinoma of the vulva were studied retrospectively to determine prognostic factors for survival. In the regression analysis, three variables were statistically significantly related to survival: smoking history, tumor size, and node status. Smokers had a 6.3 times greater risk than nonsmokers, node positivity imparted an 8.3 times greater risk than node negativity, and for each 1-cm increase in the size of the tumor, the risk of death increased by 46%. A relative decrease in survival in smokers was observed, despite a younger age and fewer positive nodes at diagnosis compared to nonsmokers. Increased surveillance in these patients may be warranted.
对136例浸润性外阴鳞状细胞癌患者进行回顾性研究，以确定生存的预后因素。在回归分析中，有三个变量与生存有统计学显著相关性：吸烟史、肿瘤大小和淋巴结状态。吸烟者的风险是非吸烟者的6.3倍，淋巴结阳性者的风险是淋巴结阴性者的8.3倍，肿瘤大小每增加1厘米，死亡风险增加46%。尽管与非吸烟者相比，吸烟者诊断时年龄较小且阳性淋巴结较少，但仍观察到其生存率相对降低。可能需要加强对这些患者的监测。
