Müller-Serten B, Vakilzadeh F
Hautklinik, Städtischen Krankenhauses, Hildesheim.
Hautarzt. 1994 Nov;45(11):772-5. doi: 10.1007/s001050050169.
We report on a 41-year-old patient who developed extensive chronic sclerodermatous graft-versus-host disease (GvHD) subsequent to an allogeneic bone marrow transplantation from his HLA-identical sister. Chronic GvHD is to be expected in 30% of bone marrow transplantations. It is a serious multisystem disorder which leads to a polymorphic clinical picture with lichenoid or sclerodermatous skin changes. It may also affect nails, hair and mucous membranes. In the absence of causal therapy GvHD should be managed with symptomatic local treatment and systemic immunosuppression.
我们报告了一名41岁的患者，他在接受来自其 HLA 相同姐姐的异基因骨髓移植后，出现了广泛的慢性硬皮病样移植物抗宿主病（GvHD）。预计30%的骨髓移植会发生慢性 GvHD。它是一种严重的多系统疾病，会导致出现苔藓样或硬皮病样皮肤改变的多形性临床表现。它也可能影响指甲、头发和黏膜。在没有因果治疗的情况下，GvHD 应采用对症局部治疗和全身免疫抑制进行处理。
