一例小儿硬皮病样慢性移植物抗宿主病病例。

A pediatric case of sclerodermatous chronic graft-versus-host disease.

作者信息

Terasaki Kenjiro, Kanekura Takuro, Setoyama Mitsuru, Kanzaki Tamotsu

机构信息

Department of Dermatology, Kagoshima University, Faculty of Medicine, Kagoshima, Japan.

出版信息

Pediatr Dermatol. 2003 Jul-Aug;20(4):327-31. doi: 10.1046/j.1525-1470.2003.20411.x.

DOI:10.1046/j.1525-1470.2003.20411.x

PMID:12869155

Abstract

We report a rare case of sclerodermatous chronic graft-versus-host disease (GVHD) in a 6-year-old boy that occurred after bone marrow transplantation for his aplastic anemia. The clinical manifestation and histopathologic findings were typical of scleroderma. Although various kinds of treatment have been tried for scleroderma, no established therapy exists. Furthermore, treating this disease is even more difficult in children. In the future, clarification of the pathogenesis of chronic GVHD and establishment of therapy will be necessary.

摘要

我们报告了一例罕见的硬皮病样慢性移植物抗宿主病（GVHD），发生在一名6岁男孩身上，该男孩因再生障碍性贫血接受骨髓移植后发病。临床表现和组织病理学发现均符合硬皮病特征。尽管针对硬皮病尝试了各种治疗方法，但尚无成熟的治疗方案。此外，在儿童中治疗这种疾病更加困难。未来，有必要阐明慢性GVHD的发病机制并确立治疗方法。