Chang M S, McNinch J, Basu R, Shutter J, Hsu R Y, Perkins C, Mar V, Suggs S, Welcher A, Li L
Department of Developmental Biology, Amgen Inc., Thousand Oaks, California 91320.
J Biol Chem. 1995 Jan 13;270(2):511-4. doi: 10.1074/jbc.270.2.511.
The megakaryocyte growth and development factor (MGDF) is a cytokine that regulates megakaryocyte development and is a ligand for the MPL receptor. In this study, we describe the genomic structure of the human MGDF gene. The MGDF gene was found to consist of seven exons and six introns spanning 8 kilobases. The protein is encoded by exons 3 through 7. The human MGDF gene has been mapped to chromosome 3q26.3. In addition to the previously described full-length cDNA, two cDNA variants were isolated from human fetal liver. Comparison of these two cDNA sequences with the genomic sequence indicates that they arise by differential splicing.
巨核细胞生长和发育因子（MGDF）是一种调节巨核细胞发育的细胞因子，是MPL受体的配体。在本研究中，我们描述了人类MGDF基因的基因组结构。发现MGDF基因由7个外显子和6个内含子组成，跨度为8千碱基。该蛋白质由外显子3至7编码。人类MGDF基因已被定位到3号染色体q26.3区域。除了先前描述的全长cDNA外，还从人胎儿肝脏中分离出两个cDNA变体。将这两个cDNA序列与基因组序列进行比较表明，它们是通过差异剪接产生的。
