Green M, Behrendt H
Am J Dis Child. 1976 Aug;130(8):816-8. doi: 10.1001/archpedi.1976.02120090026005.
An attempt has been made to elucidate the cause of hyperhidrosis in dysautonomia by testing sweat gland responsiveness to local application of heat. Heat was applied to the volar surface of the forearm with temperatures of 41.5 C and less for one to ten minutes. For each subject, the minimal duration of heating at the lowest temperature capable of evoking sweating was determined (threshold). Thresholds were significantly lower in all subjects with dysautonomia. Since one control subject, the father of a dysautonomia subject, had the highest threshold, these tests do not permit detection of the heterozygote. A reasonable explanation for enhanced sweating reactivity to local heat application is an increased excitatory state of reflex centers. These patients appear permanently on the verge of generalized sweating likely to result from minimal additional stimulation.
通过测试汗腺对局部加热的反应性，试图阐明自主神经功能障碍中多汗症的病因。将温度为41.5摄氏度及以下的热量施加到前臂掌侧表面一至十分钟。对于每个受试者，确定能够引起出汗的最低温度下的最短加热持续时间（阈值）。所有自主神经功能障碍受试者的阈值均显著较低。由于一名对照受试者，即一名自主神经功能障碍受试者的父亲，具有最高阈值，因此这些测试无法检测出杂合子。对局部加热时出汗反应增强的一个合理解释是反射中枢的兴奋性状态增加。这些患者似乎一直处于可能因最小额外刺激而导致全身出汗的边缘。
