• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中枢神经系统原代神经胶质细胞中γ-干扰素诱导基因：星形胶质细胞与小胶质细胞的比较以及Lewis大鼠与棕色挪威大鼠的比较。

Interferon-gamma-inducible genes in primary glial cells of the central nervous system: comparisons of astrocytes with microglia and Lewis with brown Norway rats.

作者信息

Vanguri P

机构信息

Department of Neurology, University of Maryland, School of Medicine, Baltimore 21201.

出版信息

J Neuroimmunol. 1995 Jan;56(1):35-43. doi: 10.1016/0165-5728(94)00131-7.

DOI:10.1016/0165-5728(94)00131-7
PMID:7822480
Abstract

We compared the expression of various interferon-gamma (IFN-gamma)-inducible mRNAs in primary rat astrocytes and microglia. Of 11 different mRNAs inducible by IFN-gamma in a macrophage cell line, RAW 264.7, only eight were induced in both types of glia, which included mRNAs encoding the transcriptional factors, IRF-1, LRF-1 and ZIF-268; members of the chemokine family, crg-2/IP-10 and MIG; beta 2-microglobulin and metallothionein-II. The patterns of induction of the mRNAs were more similar between astrocytes and microglia than with RAW 264.7 cells. Comparison of astrocytes from Lewis and Brown Norway rats showed no major differences in the levels of the crg mRNAs or in the amount of Crg-2 protein induced by IFN-gamma.

摘要

我们比较了原代大鼠星形胶质细胞和小胶质细胞中各种干扰素-γ（IFN-γ）诱导的mRNA的表达情况。在巨噬细胞系RAW 264.7中可被IFN-γ诱导的11种不同mRNA中，只有8种在这两种神经胶质细胞中均被诱导，其中包括编码转录因子IRF-1、LRF-1和ZIF-268的mRNA；趋化因子家族成员crg-2/IP-10和MIG；β2-微球蛋白和金属硫蛋白-II。与RAW 264.7细胞相比，星形胶质细胞和小胶质细胞中mRNA的诱导模式更为相似。对来自Lewis大鼠和Brown Norway大鼠的星形胶质细胞进行比较，结果显示，IFN-γ诱导的crg mRNA水平或Crg-2蛋白量没有重大差异。

相似文献

1
Interferon-gamma-inducible genes in primary glial cells of the central nervous system: comparisons of astrocytes with microglia and Lewis with brown Norway rats.中枢神经系统原代神经胶质细胞中γ-干扰素诱导基因：星形胶质细胞与小胶质细胞的比较以及Lewis大鼠与棕色挪威大鼠的比较。
J Neuroimmunol. 1995 Jan;56(1):35-43. doi: 10.1016/0165-5728(94)00131-7.
2
IFN and virus-inducible expression of an immediate early gene, crg-2/IP-10, and a delayed gene, I-A alpha in astrocytes and microglia.干扰素以及星形胶质细胞和小胶质细胞中即刻早期基因crg-2/IP-10和延迟基因I-Aα的病毒诱导表达。
J Immunol. 1994 Feb 1;152(3):1411-8.
3
A collection of mRNA species that are inducible in the RAW 264.7 mouse macrophage cell line by gamma interferon and other agents.一组mRNA种类，它们在RAW 264.7小鼠巨噬细胞系中可被γ干扰素和其他因子诱导产生。
Mol Cell Biol. 1992 Apr;12(4):1535-45. doi: 10.1128/mcb.12.4.1535-1545.1992.
4
Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma.趋化因子在弓形虫性脑炎中由星形胶质细胞、小胶质细胞和炎性白细胞差异表达，并受到γ干扰素的严格调控。
Acta Neuropathol. 2002 May;103(5):458-68. doi: 10.1007/s00401-001-0491-7. Epub 2002 Jan 31.
5
Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains.实验性变应性脑脊髓炎易感和抗性大鼠品系星形胶质细胞中肿瘤坏死因子α的差异表达
J Exp Med. 1991 Apr 1;173(4):801-11. doi: 10.1084/jem.173.4.801.
6
Regulatory mechanisms of MuRantes and CRG-2 chemokine gene induction in central nervous system glial cells by virus.
Brain Behav Immun. 1995 Dec;9(4):331-44. doi: 10.1006/brbi.1995.1031.
7
Ia expression and antigen presentation by glia: strain and cell type-specific differences among rat astrocytes and microglia.神经胶质细胞的Ia表达与抗原呈递：大鼠星形胶质细胞和小胶质细胞之间的品系及细胞类型特异性差异
J Neuroimmunol. 1997 Nov;79(2):190-201. doi: 10.1016/s0165-5728(97)00123-9.
8
IFN-gamma regulation of class II transactivator promoter IV in macrophages and microglia: involvement of the suppressors of cytokine signaling-1 protein.巨噬细胞和小胶质细胞中II类反式激活因子启动子IV的γ干扰素调节：细胞因子信号传导抑制因子-1蛋白的参与
J Immunol. 2001 Feb 15;166(4):2260-9. doi: 10.4049/jimmunol.166.4.2260.
9
Complement gene expression in mouse microglia and astrocytes in culture: comparisons with mouse peritoneal macrophages.培养的小鼠小胶质细胞和星形胶质细胞中的补体基因表达：与小鼠腹腔巨噬细胞的比较。
Neurosci Lett. 1996 Oct 4;216(3):191-4. doi: 10.1016/0304-3940(96)13040-8.
10
Expression of major histocompatibility complex molecules in rodent retina. Immunohistochemical study.啮齿动物视网膜中主要组织相容性复合体分子的表达。免疫组织化学研究。
Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1848-57.

引用本文的文献

1
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.怀孕恒河猴感染寨卡病毒会导致胎盘功能障碍和免疫病理学变化。
Nat Commun. 2018 Jan 17;9(1):263. doi: 10.1038/s41467-017-02499-9.
2
Time of day regulates subcellular trafficking, tripartite synaptic localization, and polyadenylation of the astrocytic Fabp7 mRNA.昼夜节律调节细胞内运输、三突触定位和星形胶质细胞 Fabp7 mRNA 的多聚腺苷酸化。
J Neurosci. 2012 Jan 25;32(4):1383-94. doi: 10.1523/JNEUROSCI.3228-11.2012.
3
Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration.
脂联素-2 是中枢神经系统中的趋化因子诱导剂：趋化因子配体 10（CXCL10）在脂联素-2 诱导细胞迁移中的作用。
J Biol Chem. 2011 Dec 23;286(51):43855-43870. doi: 10.1074/jbc.M111.299248. Epub 2011 Oct 26.
4
CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia?CXCL10/IP-10：子痫前期炎症与抗血管生成之间缺失的环节？
J Matern Fetal Neonatal Med. 2007 Nov;20(11):777-92. doi: 10.1080/14767050701483298.
5
Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy.孕期急性肾盂肾炎患者母体血清趋化因子CXCL10/IP-10的浓度会升高。
J Matern Fetal Neonatal Med. 2007 Oct;20(10):735-44. doi: 10.1080/14767050701511650.
6
Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model.大鼠青光眼模型中眼内压升高后视神经乳头基因表达的整体变化。
Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3161-77. doi: 10.1167/iovs.06-1282.
7
Chemokines and viral diseases of the central nervous system.趋化因子与中枢神经系统病毒性疾病
Adv Virus Res. 2001;56:127-73. doi: 10.1016/s0065-3527(01)56006-6.
8
Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.
Am J Pathol. 1997 Feb;150(2):617-30.