Are the pupils of premature infants affected by intraventricular hemorrhage?

The size and reactivity to light of the pupil in infants with intraventricular hemorrhage has been variously described in the literature. These descriptions have included miosis, reactivity to light, nonreactivity to light, and anisocoria. We studied the size and light reactivity of 20 infants with intraventricular hemorrhage compared with 30 controls. Both groups displayed a mean pupil diameter in relative darkness of 3.0 to 4.0 mm at various postconceptional ages (P > .05). The age of first response to light was about 30 weeks after conception in each group (P > .05). The severity of intraventricular hemorrhage as determined by ultrasound was not related to the pupil diameter in relative darkness. In general, the pupils of neonates are not affected by intraventricular hemorrhage.