Gilman J T
Department of Neuroscience, Miami Children's Hospital, FL.
J Child Neurol. 1994 Oct;9 Suppl 1:S20-5. doi: 10.1177/0883073894009001051.
Antiepileptic drug therapy in children can be challenging because seizure semiology and drug disposition change dramatically over time. Close monitoring of drug clearance is required in early life because of the rapid ontogenesis of drug-eliminating organs. Large variations in serum peak and trough antiepileptic drug concentrations increase the risk for both adverse drug effects and unsatisfactory seizure control. Antiepileptic drug adverse effects also differ, probably relative to different receptor sensitivities in children. Failure to appreciate the developmental differences between children and adults can result in medication noncompliance, breakthrough seizures, and unacceptable adverse effects.
儿童抗癫痫药物治疗颇具挑战性，因为癫痫发作症状学和药物处置会随时间发生显著变化。由于药物消除器官的快速发育，在儿童早期需要密切监测药物清除情况。血清中抗癫痫药物峰浓度和谷浓度的大幅波动增加了药物不良反应和癫痫控制不佳的风险。抗癫痫药物的不良反应也有所不同，这可能与儿童不同的受体敏感性有关。未能认识到儿童与成人之间的发育差异可能导致药物治疗依从性差、癫痫发作以及不可接受的不良反应。
