Steinborn B, Galas-Zgorzalewicz B
Department of Developmental Neurology, University of Medical Sciences, Poznań, Poland.
Funct Neurol. 1993 Nov-Dec;8(6):415-22.
The results of a 36 month observation of therapeutic effects of various schemes of long-term monitored treatment of primary generalized epilepsy with Valproate (VPA) derivatives is presented. A hundred children and adolescents aged 5-15 constituted the experimental group. In each of 3 groups the drug was administered in individually assessed doses. An optimal antiepileptic clinical effect of VPA was achieved thanks to therapeutic monitoring, especially pharmacokinetic studies.
本文呈现了对丙戊酸盐（VPA）衍生物长期监测治疗原发性全身性癫痫各种方案的36个月治疗效果观察结果。100名5至15岁的儿童和青少年构成了实验组。在3个组中的每一组，药物均以个体评估剂量给药。由于治疗监测，特别是药代动力学研究，VPA取得了最佳的抗癫痫临床效果。
