Clinical and pharmacokinetic observations on valproate: a 3 year follow-up study in 100 children with generalized epilepsy.

The results of a 36 month observation of therapeutic effects of various schemes of long-term monitored treatment of primary generalized epilepsy with Valproate (VPA) derivatives is presented. A hundred children and adolescents aged 5-15 constituted the experimental group. In each of 3 groups the drug was administered in individually assessed doses. An optimal antiepileptic clinical effect of VPA was achieved thanks to therapeutic monitoring, especially pharmacokinetic studies.