Aldman A, Lewis D H, Elfström J, Mårtensson J, Larsson J
Department of Surgery, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Int Angiol. 1994 Sep;13(3):246-50.
Revascularization of acutely ischemic muscle tissue is followed by edema, decreased oxygen utilization, increased vascular resistance and massive efflux of intracellular compounds indicating loss of cellular integrity, with resultant irreversible damage. In this pig hindlimb study, 8 pigs were submitted to standardized subtotal ischemia of one leg and mannitol was administered i.v. prior to and during 2.5 hours of reperfusion. Compared to 9 controls, the mannitol treated pigs had increased blood flow to the legs, increased oxygen consumption and decreased release of intracellular compounds (CK). This indicates that mannitol attenuates the ischemia/reperfusion syndrome. Muscle energy metabolic parameters showed a similar response to ischemia for both mannitol-treated pigs and controls and no differences in recovery were detected during 2.5 hours of reperfusion between the groups.
急性缺血性肌肉组织再灌注后会出现水肿、氧利用减少、血管阻力增加以及细胞内化合物大量外流，这表明细胞完整性丧失，最终导致不可逆损伤。在这项猪后肢研究中，8头猪的一条腿接受了标准化的次全缺血处理，并在再灌注的2.5小时期间及之前静脉注射甘露醇。与9只对照猪相比，接受甘露醇治疗的猪腿部血流量增加、氧消耗增加且细胞内化合物（肌酸激酶）释放减少。这表明甘露醇可减轻缺血/再灌注综合征。肌肉能量代谢参数显示，接受甘露醇治疗的猪和对照猪对缺血的反应相似，且两组在2.5小时再灌注期间未检测到恢复情况的差异。
