Kawakami K, Ishiyama T, Onizuka T, Hino K, Tomoyasu S, Tsuruoka N
Department of Hematology, Showa University School of Medicine.
Rinsho Ketsueki. 1994 Nov;35(11):1305-9.
A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone. Subsequently, he developed pneumonia for which he received antibiotics, an antifungal agent and granulocyte colony-stimulating factor (G-CSF) twice. Myeloma cells appeared in the peripheral blood 10 days after the second G-CSF course. In addition, skin tumors developed on his extremities and chest 14 days after the second use of G-CSF. The skin tumors consisted of immunohistochemically IgD (lambda)-positive myeloma cells. The skin tumors may have been formed from the bone marrow by metastasis, a very rare occurrence in multiple myeloma. Before the development of the tumors we administered G-CSF, which may also have been related to the formation of the skin tumors.
一名66岁男性因IgD（λ）型多发性骨髓瘤接受治疗，使用美法仑每日2mg及泼尼松龙每日20mg。随后，他患上肺炎，为此接受了抗生素、抗真菌药治疗，并两次使用粒细胞集落刺激因子（G-CSF）。第二次使用G-CSF疗程后10天，外周血中出现骨髓瘤细胞。此外，在第二次使用G-CSF后14天，其四肢和胸部出现皮肤肿瘤。皮肤肿瘤经免疫组织化学检测由IgD（λ）阳性骨髓瘤细胞构成。这些皮肤肿瘤可能是骨髓瘤细胞通过转移从骨髓形成的，这在多发性骨髓瘤中非常罕见。在肿瘤出现之前我们使用了G-CSF，这可能也与皮肤肿瘤的形成有关。
