Matano S, Kobayashi K, Nakamura S, Yoshida T
Department of Internal Medicine, Tonami General Hospital.
Rinsho Ketsueki. 1994 Nov;35(11):1310-4.
Multiple myeloma (IgG kappa + IgA kappa type, clinical stage IA) was diagnosed in a 82-year-old woman in January 1986. Chemotherapy (melphalan, prednisolone, vindesine, cyclophosphamide), caused prolonged myelosuppression. Therefore she was given other treatment. In October 1992, her peripheral blood examination demonstrated 2% blastic cells and 12% eosinophils. Bone marrow aspiration showed dysplastic features of trilineage blood cells with 4.8% myeloblasts. The karyotype of bone marrow cells from this patients was 47, XX, +der(1)t(1;7) (p11;p11), -7, +8. A diagnosis of therapy-related myelodysplastic syndrome (refractory anemia) was established. Eleven months after diagnosis of myelodysplastic syndrome, she is alive without leukemic transformation.
1986年1月，一名82岁女性被诊断为多发性骨髓瘤（IgG κ + IgA κ型，临床分期IA期）。化疗（美法仑、泼尼松龙、长春地辛、环磷酰胺）导致长期骨髓抑制。因此，她接受了其他治疗。1992年10月，她的外周血检查显示有2%的原始细胞和12%的嗜酸性粒细胞。骨髓穿刺显示三系血细胞发育异常，原始粒细胞占4.8%。该患者骨髓细胞的核型为47, XX, +der(1)t(1;7)(p11;p11), -7, +8。确诊为治疗相关的骨髓增生异常综合征（难治性贫血）。在诊断为骨髓增生异常综合征11个月后，她仍然存活，未发生白血病转化。
