Yokoi K, Akaike M, Shigekiyo T, Saito S
Department of Internal Medicine, Yoshinogawa Hospital.
Nihon Ronen Igakkai Zasshi. 1994 Sep;31(9):716-9. doi: 10.3143/geriatrics.31.716.
We report a patient with Takayasu's arteritis associated with antiphospholipid antibodies. An 84-year-old woman gradually developed gait and visual disturbances, dementia, myocardial infarction, and gangrene in all four limbs during a period of 8 years. Persistent inflammatory signs also continued for at least 8 years. Positive reaction for lupus anticoagulant by the diluted Russel viper venous time and positive reactions for cardiolipin antibodies were confirmed. However, she did not develop SLE. MR angiography revealed multiple and extensive occlusive changes in large vessels such as the aorta and its major branches. We believe antiphospholipid antibodies may have been related to severe occlusive vasculopathy in this patient.
我们报告了一名患有高安动脉炎且伴有抗磷脂抗体的患者。一名84岁女性在8年期间逐渐出现步态和视觉障碍、痴呆、心肌梗死以及四肢坏疽。持续性炎症体征也持续了至少8年。通过稀释的蝰蛇静脉时间检测狼疮抗凝物呈阳性反应，且心磷脂抗体检测也呈阳性反应。然而，她并未发展为系统性红斑狼疮。磁共振血管造影显示主动脉及其主要分支等大血管出现多处广泛的闭塞性改变。我们认为抗磷脂抗体可能与该患者严重的闭塞性血管病有关。
