Yokoi K, Hosoi E, Akaike M, Shigekiyo T, Saito S
Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan.
Angiology. 1996 Mar;47(3):315-9. doi: 10.1177/000331979604700317.
The authors describe 2 patients with Takayasu's arteritis in whom lupus anticoagulant was positive and the titer of anticardiolipin antibody was elevated. One patient developed diffusely stenotic and occlusive changes in the multiple larger arteries. Histology of the small-sized arteries in another patient showed occlusive vasculitis without thrombosis, in addition to the findings in large-sized arteries compatible with Takayasu's disease. These findings are uncommon in Takayasu's arteritis. These findings suggest that antiphospholipid antibodies may have contributed to the pathogenesis of the extensive vasculopathy and may have triggered vasculitis in these patients.
作者描述了2例高安动脉炎患者，其狼疮抗凝物呈阳性，抗心磷脂抗体滴度升高。1例患者多条较大动脉出现弥漫性狭窄和闭塞性改变。另1例患者除了有与高安病相符的大动脉表现外，小动脉组织学显示为无血栓形成的闭塞性血管炎。这些发现于高安动脉炎中并不常见。这些发现提示抗磷脂抗体可能在广泛血管病变的发病机制中起作用，并可能触发了这些患者的血管炎。
