Hartwig M, Steinmann G
Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Mech Ageing Dev. 1994 Aug;75(2):151-6. doi: 10.1016/0047-6374(94)90083-3.
The age-associated chronic thymus involution is interpreted to occur due to cytolytic depletion of thymic stromal tissue whose cells present altered self-peptides. Using simplified assumptions and based on morphometric data on thymic involution in man, the chance for a single protein to be altered is estimated to be in the range of 2-4 x 10(-6) per year. The corresponding mutation rate is compatible with that derived from both evolutionary and direct studies, thus supporting the proposed model.
与年龄相关的慢性胸腺退化被认为是由于胸腺基质组织的细胞溶解耗竭所致，这些细胞呈现出改变的自身肽。利用简化的假设并基于人类胸腺退化的形态计量学数据，估计单一蛋白质每年发生改变的几率在2 - 4×10⁻⁶范围内。相应的突变率与从进化和直接研究中得出的突变率相符，从而支持了所提出的模型。
