骨髓、胸腺与血液：一生之中的变化
BONE MARROW, THYMUS AND BLOOD: CHANGES ACROSS THE LIFESPAN.
出版信息
Aging health. 2009 Jun 1;5(3):385-393. doi: 10.2217/ahe.09.31.
Abstract
The aim of this review is to present age-related changes in the bone marrow and thymus and their effects in later life. Age-related hematologic changes are marked by a decline in marrow cellularity, increased risk of myeloproliferative disorders and anemia, and a decline in adaptive immunity. The exact mechanisms that produce these changes remain undefined. For the most part, the changes in function that are a consequence of aging alone rarely have meaningful clinical consequences. However, in the face of the stresses induced by other illnesses, the decreased physiologic reserve can slow or prevent an appropriate response to the stressors.
摘要
本综述的目的是阐述骨髓和胸腺与年龄相关的变化及其对晚年生活的影响。与年龄相关的血液学变化表现为骨髓细胞数量减少、骨髓增殖性疾病和贫血风险增加，以及适应性免疫功能下降。导致这些变化的确切机制尚不清楚。在大多数情况下，仅由衰老引起的功能变化很少产生有意义的临床后果。然而，面对其他疾病引发的压力，生理储备的减少可能会减缓或阻碍对压力源的适当反应。
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