骨髓、胸腺与血液：一生之中的变化
BONE MARROW, THYMUS AND BLOOD: CHANGES ACROSS THE LIFESPAN.
出版信息
Aging health. 2009 Jun 1;5(3):385-393. doi: 10.2217/ahe.09.31.
Abstract
The aim of this review is to present age-related changes in the bone marrow and thymus and their effects in later life. Age-related hematologic changes are marked by a decline in marrow cellularity, increased risk of myeloproliferative disorders and anemia, and a decline in adaptive immunity. The exact mechanisms that produce these changes remain undefined. For the most part, the changes in function that are a consequence of aging alone rarely have meaningful clinical consequences. However, in the face of the stresses induced by other illnesses, the decreased physiologic reserve can slow or prevent an appropriate response to the stressors.
摘要
本综述的目的是阐述骨髓和胸腺与年龄相关的变化及其对晚年生活的影响。与年龄相关的血液学变化表现为骨髓细胞数量减少、骨髓增殖性疾病和贫血风险增加，以及适应性免疫功能下降。导致这些变化的确切机制尚不清楚。在大多数情况下，仅由衰老引起的功能变化很少产生有意义的临床后果。然而，面对其他疾病引发的压力，生理储备的减少可能会减缓或阻碍对压力源的适当反应。
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本文引用的文献
1
Hematopoietic stem cells and the aging hematopoietic system.造血干细胞与衰老的造血系统。
Semin Hematol. 2008 Oct;45(4):218-24. doi: 10.1053/j.seminhematol.2008.07.010.
2
Lower red blood cell counts in middle-aged subjects with shorter peripheral blood leukocyte telomere length.外周血白细胞端粒长度较短的中年受试者红细胞计数较低。
Aging Cell. 2008 Oct;7(5):700-5. doi: 10.1111/j.1474-9726.2008.00419.x. Epub 2008 Jul 28.
3
Study of anemia in long-term care (SALT): prevalence of anemia and its relationship with the risk of falls in nursing home residents.长期护理中的贫血研究（SALT）：疗养院居民贫血的患病率及其与跌倒风险的关系。
Curr Med Res Opin. 2008 Aug;24(8):2139-49. doi: 10.1185/03007990802215844. Epub 2008 Jun 17.
4
Prevalence of anaemia in older persons: systematic review.老年人贫血患病率：系统评价
BMC Geriatr. 2008 Jan 14;8:1. doi: 10.1186/1471-2318-8-1.
5
Epidemiology of myelodysplastic syndromes.骨髓增生异常综合征的流行病学
Semin Hematol. 2008 Jan;45(1):8-13. doi: 10.1053/j.seminhematol.2007.10.003.
6
Prevalence of anemia in the nursing home: contribution of chronic kidney disease.养老院中贫血的患病率：慢性肾脏病的影响
J Am Geriatr Soc. 2007 Oct;55(10):1566-70. doi: 10.1111/j.1532-5415.2007.01389.x. Epub 2007 Aug 28.
7
Immunosenescence: deficits in adaptive immunity in the elderly.免疫衰老：老年人适应性免疫功能缺陷。
Tissue Antigens. 2007 Sep;70(3):179-89. doi: 10.1111/j.1399-0039.2007.00891.x.
8
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J Pathol. 2007 Jan;211(2):144-56. doi: 10.1002/path.2104.
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