Scott R N, Faraci R P, Hough A, Chretien P B
Ann Surg. 1976 Aug;184(2):205-11. doi: 10.1097/00000658-197608000-00012.
Three methods of closing bronchial stumps were evaluated in 90 dogs undergoing left pneumonectomy:interrupted 3-0 silk sutures, interrupted 3-0 nylon sutures, and stapling with an automatic device. The dogs were sacrificed at 24 hours, 3, 5, 7, 10, and 14 days after pneumonectomy. Brochial stump leakage pressures and histological studies were performed on all specimens. Differences in the exudative reaction between silk and staple closures were significant on day 5(238.19+/- 23.28 SD PMN's/HPF in silk closures, 34.95+/- 20.37 SD PMN's/HPF in staple closures) and therafter(P less than 0.001). The reaction to nylon was intermediate between silk and staple. Collagen levels were highest at all periods for staple closures. Staple leakage pressures were greater than silk or nylon(day 5: 145.3 mm Hg +/- 64.9 SD in staple closures, 40.2 mm Hg +/- 15.4 SD in silk closures). These results have clinical relevance to the selection of suture materials for stump closures.
在90只接受左肺切除术的犬中评估了三种闭合支气管残端的方法：3-0丝线间断缝合、3-0尼龙线间断缝合以及使用自动装置吻合。在肺切除术后24小时、3天、5天、7天、10天和14天处死这些犬。对所有标本进行支气管残端漏出压力测定和组织学研究。丝线缝合与吻合器闭合之间渗出反应的差异在第5天（丝线缝合为238.19±23.28标准差个中性粒细胞/高倍视野，吻合器闭合为34.95±20.37标准差个中性粒细胞/高倍视野）及之后有显著性差异（P<0.001）。对尼龙线的反应介于丝线和吻合器之间。吻合器闭合在所有时间段的胶原水平最高。吻合器的漏出压力大于丝线或尼龙线（第5天：吻合器闭合为145.3 mmHg±64.9标准差，丝线缝合为40.2 mmHg±15.4标准差）。这些结果对于选择用于残端闭合的缝合材料具有临床意义。
