Nisticò G, De Girolamo G, Preziosi P
Arch Int Pharmacodyn Ther. 1976 Apr;220(2):339-43.
In adult fowls with cannulae chronically implanted into the IIIrd cerebral ventricle or into the hypothalamus, the effects of various hydrosoluble antipyretics, given intraventricularly, on bacterial pyrogen fever were studied. It has been shown that fever evoked by intrahypothalamic or intraventricular infusion of O somatic antigen of Shigella Dysenteriae was reduced by intraventricular administration of acetylsalicylate-lysine, indomethacin-methylglucamine or ibuprofen-lysine given during the febrile plateau. However, a 3-day intraventricular pretreatment with acetylsalicylate or indomethacin, or a single administration 30 min before, did not prevent fever by subsequent intraventricular or intrahypothalamic injection of pyrogen. On the contrary, intraventricular infusion of indomethacin or acetylsalicylate substantially reduced pyrogen fever when given after pyrogen latency period, e.g. just at the beginning of the febrile response. A possible involvement of E prostaglandins as mediator to pyrogen fever is discussed.
在成年家禽中，将套管长期植入第三脑室或下丘脑，研究了脑室内给予各种水溶性解热药对细菌致热原性发热的影响。结果表明，在发热高峰期脑室内给予乙酰水杨酸赖氨酸、吲哚美辛甲基葡糖胺或布洛芬赖氨酸，可降低下丘脑内或脑室内注入痢疾志贺氏菌O体细胞抗原所引起的发热。然而，脑室内用乙酰水杨酸或吲哚美辛进行3天预处理，或在30分钟前单次给药，均不能预防随后脑室内或下丘脑内注射致热原所引起的发热。相反，在致热潜伏期后，例如在发热反应刚开始时脑室内注入吲哚美辛或乙酰水杨酸，可显著降低致热原性发热。文中讨论了E前列腺素作为致热原性发热介质的可能作用。
