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抗精神病药物和抗抑郁药物对大鼠脑内谷氨酸受体mRNA水平无影响。

Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains.

作者信息

Oretti R G, Spurlock G, Buckland P R, McGuffin P

机构信息

Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.

出版信息

Neurosci Lett. 1994 Aug 15;177(1-2):39-43. doi: 10.1016/0304-3940(94)90039-6.

DOI:10.1016/0304-3940(94)90039-6
PMID:7824178
Abstract

By employing multiprobe oligonucleotide solution hybridisation (MOSH) we have measured the levels of mRNA encoding the NMDA receptor subtypes (R1, R2A, R2B and R2C) and the non-NMDA glutamate receptor subtypes (GluR1, 2, 3, and 4) within rat brain following, 1-32 days of antipsychotic or antidepressant drug administration. The results suggest that the drugs studied do not significantly alter rat glutamatergic system mRNA levels when compared to controls.

摘要

通过采用多探针寡核苷酸溶液杂交（MOSH）技术，我们测定了在给予抗精神病药物或抗抑郁药物1至32天后，大鼠脑内编码NMDA受体亚型（R1、R2A、R2B和R2C）以及非NMDA谷氨酸受体亚型（GluR1、2、3和4）的mRNA水平。结果表明，与对照组相比，所研究的药物并未显著改变大鼠谷氨酸能系统的mRNA水平。

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