• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Ras farnesyltransferase: a new therapeutic target.

作者信息

Leonard D M

机构信息

Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.

出版信息

J Med Chem. 1997 Sep 12;40(19):2971-90. doi: 10.1021/jm970226l.

DOI:10.1021/jm970226l
PMID:9301658
Abstract
摘要

相似文献

1
Ras farnesyltransferase: a new therapeutic target.Ras法尼基转移酶：一个新的治疗靶点。
J Med Chem. 1997 Sep 12;40(19):2971-90. doi: 10.1021/jm970226l.
2
Inhibitors of farnesyltransferase and Ras processing peptidase.
Biochem Biophys Res Commun. 1995 Dec 26;217(3):728-32. doi: 10.1006/bbrc.1995.2833.
3
[Inhibitors of Ras farnesylation: tomorrow's anticancer agents?].[Ras法尼基化抑制剂：未来的抗癌药物？]
Bull Cancer. 1997 Jun;84(6):635-42.
4
Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase.
J Med Chem. 1997 Jun 6;40(12):1763-7. doi: 10.1021/jm9701177.
5
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.非肽类Ras CAAX模拟物作为强效法尼基转移酶抑制剂的设计与合成
J Med Chem. 1996 Jan 5;39(1):217-23. doi: 10.1021/jm950414g.
6
2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.作为受限氨基酸的2-取代哌嗪。在法尼基转移酶强效非羧酸抑制剂合成中的应用。
J Med Chem. 1996 Mar 29;39(7):1345-8. doi: 10.1021/jm9508090.
7
Protein prenylation: key to ras function and cancer intervention?蛋白质异戊二烯化：Ras功能及癌症干预的关键？
Cell Growth Differ. 1992 Jul;3(7):461-9.
8
Ras farnesyltransferase inhibition: a novel and safe approach for cancer chemotherapy.Ras法尼基转移酶抑制：一种用于癌症化疗的新型安全方法。
Acta Pharmacol Sin. 2000 May;21(5):396-404.
9
Protection against malignant conversion in SENCAR mouse skin by all trans retinoic acid: inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization.全反式维甲酸对SENCAR小鼠皮肤恶性转化的防护作用：对ras p21加工酶法尼基转移酶的抑制及Ha-ras p21膜定位的影响
Mol Carcinog. 1996 Sep;17(1):13-22. doi: 10.1002/(SICI)1098-2744(199609)17:1<13::AID-MC3>3.0.CO;2-L.
10
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.蛋白质法尼基转移酶抑制剂作为基于信号传导的抗癌药物的研发。
Prog Cell Cycle Res. 2003;5:211-7.

引用本文的文献

1
The complex journey of targeting RAS in oncology.肿瘤学中靶向RAS的复杂历程。
BMC Cancer. 2025 Jul 1;25(1):1053. doi: 10.1186/s12885-025-14033-y.
2
Evolution of computational techniques against various KRAS mutants in search for therapeutic drugs: a review article.寻找治疗药物过程中针对各种KRAS突变体的计算技术进展：一篇综述文章
Cancer Chemother Pharmacol. 2025 Apr 7;95(1):52. doi: 10.1007/s00280-025-04767-8.
3
Exploration of a Novel ICMT Inhibitor with More Solubility than Cysmethynil against Membrane Localization of KRAS Mutant in Colorectal Cancer.
探索一种新型 ICMT 抑制剂，与 Cysmethynil 相比，该抑制剂对结直肠癌 KRAS 突变体的膜定位具有更高的溶解性。
Curr Comput Aided Drug Des. 2024;20(7):1055-1069. doi: 10.2174/0115734099264451231003172217.
4
Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase.文库筛选、体内确证以及五肽序列作为蛋白质法尼基转移酶底物的结构和生物信息学分析。
Int J Mol Sci. 2024 May 13;25(10):5324. doi: 10.3390/ijms25105324.
5
Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines.通过锂化进行光催化和动力学拆分，得到手性富集的 2-芳基哌嗪。
Org Lett. 2023 Feb 17;25(6):987-991. doi: 10.1021/acs.orglett.3c00074. Epub 2023 Feb 3.
6
Protein Farnesylation on Nasopharyngeal Carcinoma, Molecular Background and Its Potential as a Therapeutic Target.蛋白质法尼基化修饰在鼻咽癌中的作用、分子机制及其作为治疗靶点的潜力
Cancers (Basel). 2022 Jun 8;14(12):2826. doi: 10.3390/cancers14122826.
7
RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics.RAS 功能在癌细胞中：将膜生物学和生物化学转化为新的治疗方法。
Biochem J. 2020 Aug 14;477(15):2893-2919. doi: 10.1042/BCJ20190839.
8
Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.类异戊二烯和蛋白质的类异戊二烯化：在阿尔茨海默病发病机制和治疗干预中的意义。
Crit Rev Biochem Mol Biol. 2018 Jun;53(3):279-310. doi: 10.1080/10409238.2018.1458070.
9
Opportunities and challenges for direct C-H functionalization of piperazines.哌嗪直接C-H官能化的机遇与挑战
Beilstein J Org Chem. 2016 Apr 13;12:702-15. doi: 10.3762/bjoc.12.70. eCollection 2016.
10
Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives.氨基修饰的紫苏醇衍生物的合成及其抗增殖作用
Molecules. 2014 May 22;19(5):6671-82. doi: 10.3390/molecules19056671.