Denis F, Tabaste J L, Ranger-Rogez S
Laboratoire de Bactériologie-Virologie, CHU Dupuytren, Limoges, France.
Pathol Biol (Paris). 1994 May;42(5):533-8.
The risk of perinatal B virus transmission is estimated in France on results of limited studies carried out during a long period and essentially in metropolitan area. Systematic screening for HBsAg in pregnancy was decided in February 1992 in France. In order to obtain national data on HBsAg prevalence of pregnant women, the authors have summarized the results obtained from twelve French university hospitals during one year. Among the 21,476 pregnant women studied (French: 16,351 and immigrant: 5,125), the total HBsAg prevalence was 0.72% and was significantly higher in the immigrant women group (2.56%) when compared to that of French women (0.15%). The HBsAg prevalence increased from Mediterranean area (1.75%) to SubSaharan Africa (4.61%) and South East Asia (5.45%). Important variations were observed between the centers (from 0.13 to 2.99%). Among the HBsAg carriers, 16.5% were HBeAg and/or HBV-DNA positive in their serum. The only means to prevent each year in France around 850 chronic HBV infections by vaccination of the neonates consist in systematic HBsAg screening.
法国根据长期开展且主要在大城市地区进行的有限研究结果，对围产期B病毒传播风险进行了评估。1992年2月，法国决定在孕期对乙肝表面抗原（HBsAg）进行系统筛查。为获取法国孕妇HBsAg流行率的全国数据，作者总结了12家法国大学医院在一年时间内取得的结果。在研究的21476名孕妇中（法国本土孕妇：16351名，移民孕妇：5125名），HBsAg总流行率为0.72%，与法国本土孕妇组（0.15%）相比，移民孕妇组的流行率（2.56%）显著更高。HBsAg流行率从地中海地区（1.75%）到撒哈拉以南非洲地区（4.61%）以及东南亚地区（5.45%）呈上升趋势。各中心之间观察到了显著差异（从0.13%至2.99%）。在HBsAg携带者中，16.5%的人血清中乙肝e抗原（HBeAg）和/或乙肝病毒DNA（HBV-DNA）呈阳性。在法国，每年通过新生儿疫苗接种预防约850例慢性乙肝病毒感染的唯一方法就是进行HBsAg系统筛查。
