Jähkel M, Oehler J, Schumacher H E
Institute of Biology, Medical School Carl Gustav Carus, Dresden, Germany.
Pharmacol Biochem Behav. 1994 Oct;49(2):263-9. doi: 10.1016/0091-3057(94)90419-7.
Mice differentiated by their running wheel activity into low and high active animals were chronically treated with the nootropics meclophenoxate, piracetam, vinpocetine, methylglucaminorotate, and the antidepressants lithium, desipramine, amitriptyline, and clomipramine. The influence of chronic drug treatment on running-wheel activity and open field locomotor behaviour was analyzed. Whereas with antidepressants rather sedative effects were observed in both activity types, the effects of nootropics were different in high and low active mice. Running-wheel scores increased in low active mice but decreased in high-active animals with an improvement in efficiency of locomotor behaviour in the open field of these mice after chronic nootropic treatment. In general, the effects of antidepressants seemed to be more uniform than those of the nootropics used.
根据跑步轮活动将小鼠分为低活动和高活动动物，然后长期用益智药氯酯醒、吡拉西坦、长春西汀、葡甲胺基烟酸盐，以及抗抑郁药锂盐、地昔帕明、阿米替林和氯米帕明进行治疗。分析了长期药物治疗对跑步轮活动和旷场运动行为的影响。虽然在两种活动类型中都观察到抗抑郁药有相当的镇静作用，但益智药对高活动和低活动小鼠的影响有所不同。长期给予益智药治疗后，低活动小鼠的跑步轮得分增加，而高活动动物的得分降低，且这些小鼠在旷场中的运动行为效率有所提高。总体而言，抗抑郁药的作用似乎比所用益智药的作用更具一致性。
