Alonso S J, Navarro E, Rodriguez M
Department of Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
Pharmacol Biochem Behav. 1994 Oct;49(2):353-8. doi: 10.1016/0091-3057(94)90433-2.
It has been suggested that stress during the initial stages of human life may serve as a predisposing factor to mental illness. Recently, we reported that in pregnant rats, stress induces an increase of behavioral depression in the female offsprings when adult. This article describes the effect of prenatal stress on central dopaminergic transmission during adulthood. The offspring of stressed mothers showed an increase of behavioral depression in the Porsolt test and a reduction of DOPAC, HVA, and DOPAC/DA index in the n. accumbens. The effect on the right accumbens was more marked than on the left. A great body of information exists to suggest that depression is related to a decrease of dopaminergic neurotransmission, and the present data provide new evidence in support of the hypothesis that maternal stress during gestation increases the risk of depression in the offspring. We are also reporting a hitherto uncommented relationship between behavioral depression in the Porsolt test and the decrease of dopamine transmission in the n. accumbens.
有人提出，人类生命早期阶段的压力可能是精神疾病的一个诱发因素。最近，我们报道，在怀孕大鼠中，压力会导致雌性后代成年后行为抑郁增加。本文描述了产前压力对成年期中枢多巴胺能传递的影响。应激母亲的后代在波索尔特测试中行为抑郁增加，伏隔核中3,4-二羟基苯乙酸（DOPAC）、高香草酸（HVA）和DOPAC/多巴胺（DA）指数降低。对右侧伏隔核的影响比对左侧更明显。大量信息表明，抑郁症与多巴胺能神经传递减少有关，目前的数据为孕期母亲压力会增加后代患抑郁症风险这一假说提供了新证据。我们还报告了波索尔特测试中的行为抑郁与伏隔核中多巴胺传递减少之间一种迄今未被评论的关系。
