Bernengo M G, Zina A, Zina G
Br J Dermatol. 1976 Jul;95(1):45-9.
The clinical course of a patient with acute lymphoid immunoblastic leukaemia and prominent nodular haemorrhagic skin lesions is described. Cytological, cytochemical and electronmicroscopic studies were performed on bone marrow and skin blast cells. The absence of surface immunoglobulins and of the other markers for B lymphocytes (EA and EAC rosettes) and the presence of 30% of spontaneous sheep erythrocyte rosettes excluding an acute leukaemia with Burkitt's tumour cells, suggest that T cells are involved. Complete haematological and cutaneous remission was obtained with prednisone therapy.
描述了一名患有急性淋巴免疫母细胞白血病并伴有明显结节性出血性皮肤病变患者的临床病程。对骨髓和皮肤原始细胞进行了细胞学、细胞化学和电子显微镜研究。缺乏表面免疫球蛋白以及B淋巴细胞的其他标志物（EA和EAC玫瑰花结），且存在30%的自发绵羊红细胞玫瑰花结，排除了伯基特肿瘤细胞引起的急性白血病，提示T细胞参与其中。使用泼尼松治疗后实现了血液学和皮肤的完全缓解。
