Toben H R, Smith R G
Clin Exp Immunol. 1977 Feb;27(2):292-302.
A patient is described who presented with a disease clinically resembling chronic lymphocytic leukaemia, characterized by generalized lymphadenopathy, pleural and peritoneal effusions, a blood lymphocyte count of 700,000/mul and failure to respond to conventional therapy. At least 95% of these cells formed rosettes with sheep erythrocytes (E) and with erythrocytes coated with 19S antibodies and complement (EAC). All of these cells bound rabbit anti-human thymocyte serum; this serum bound to 0--22% of the lymphocytes from twenty other patients with chronic lymphocytic leukaemia. These unusual cells did not bear surface immunoglobulin detectable by immunofluorescence. The clinical and cellular features of this malignancy are compared to previously reported cases of T cell chronic lymphocytic leukaemia. As this case illustrates, T-cell chronic lymphocytic leukaemia may present without skin lesions and may be a more aggressive disease than the more common B-cell neoplasm.
本文描述了一名患者，其临床表现类似于慢性淋巴细胞白血病，特征为全身性淋巴结肿大、胸腔和腹腔积液、血液淋巴细胞计数为700,000/微升且对传统治疗无反应。这些细胞中至少95%与绵羊红细胞（E）以及与被19S抗体和补体包被的红细胞（EAC）形成玫瑰花结。所有这些细胞均与兔抗人胸腺细胞血清结合；该血清与其他20例慢性淋巴细胞白血病患者的0 - 22%的淋巴细胞结合。这些异常细胞未检测到可通过免疫荧光法检测的表面免疫球蛋白。将这种恶性肿瘤的临床和细胞特征与先前报道的T细胞慢性淋巴细胞白血病病例进行了比较。正如该病例所示，T细胞慢性淋巴细胞白血病可能不伴有皮肤病变，并且可能是一种比更常见的B细胞肿瘤更具侵袭性的疾病。
