Gasic S
Klinischen Abteilung für Endokrinologie und Stoffwechsel, Universitäts-klinik für Innere Medizin III, Wien.
Wien Med Wochenschr. 1994;144(14-15):338-42.
The knowledge of basic electrophysiologic functions and of ion fluxes across the cell membrane of excitable tissues seems essential for the understanding of the action mode of antiarrhythmic drugs. Therefore, the rather complex physiological interconnections at the membrane site are briefly reviewed. Moreover, the interaction mechanisms of antiarrhythmic drugs with transmembraneous ion movements are discussed. The classification of antiarrhythmic agents as proposed by Vaughan-Williams is critically discussed, emphasizing that each drug has a particular electrophysiologic action.
了解基本的电生理功能以及可兴奋组织细胞膜上的离子通量，对于理解抗心律失常药物的作用方式似乎至关重要。因此，本文简要回顾了膜部位相当复杂的生理联系。此外，还讨论了抗心律失常药物与跨膜离子运动的相互作用机制。文中批判性地讨论了由 Vaughan-Williams 提出的抗心律失常药物分类，强调每种药物都有特定的电生理作用。
