Roden D M, George A L
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Annu Rev Med. 1996;47:135-48. doi: 10.1146/annurev.med.47.1.135.
The electrical activity of cardiac tissue is determined by the highly regulated flow of ions across the cell membrane during the cardiac action potential. Ion channels are pore-forming proteins through which these electric currents flow. In this review, the ion currents that underlie the action potential are first described. Then, the way in which expression of individual ion-channel genes results in such ion currents is discussed. Finally, the concept that arrhythmias may be due to abnormalities of structure, function, or number of ion channels, or the way in which they respond to abnormalities in their environment (such as acute ischemia), is reviewed. Further understanding of the molecular mechanisms underlying normal and abnormal cardiac electrophysiologic behavior should allow the development of safer and more effective antiarrhythmic interventions.
心脏组织的电活动由心脏动作电位期间离子跨细胞膜的高度调节流动所决定。离子通道是形成孔道的蛋白质，电流通过这些孔道流动。在本综述中，首先描述了构成动作电位基础的离子电流。然后，讨论了单个离子通道基因的表达导致此类离子电流的方式。最后，回顾了心律失常可能归因于离子通道的结构、功能或数量异常，或者它们对环境异常（如急性缺血）的反应方式这一概念。对正常和异常心脏电生理行为背后分子机制的进一步理解应有助于开发更安全、更有效的抗心律失常干预措施。
