Martin-Boglind L, Wanger P
Stockholm University College of Health Sciences, Solna, Sweden.
Acta Ophthalmol (Copenh). 1994 Aug;72(4):423-8. doi: 10.1111/j.1755-3768.1994.tb02789.x.
In order to find out to which extent high-pass resolution perimetry would detect any changes in patients treated for glaucoma, resolution perimetry results were evaluated from 56 glaucoma patients and 15 untreated ocular hypertensive patients followed for 2 to 3 years. Fifty-nine of the 71 examined patients showed lower resolution thresholds, i.e. increased sensitivity, after 2 years, compared to initial values. The threshold decrease was significantly larger in the treated glaucoma patients (median 1.22 dB) than in the untreated ocular hypertensive patients (0.48 dB). The threshold decrease in the untreated ocular hypertensive group corresponds to the previously described learning effect. In 35 of the 56 treated glaucoma patients the thresholds improved more than 0.84 dB, the upper confidence limit in the untreated group, which may indicate a beneficial effect of antiglaucoma therapy in these patients. The threshold change was unrelated to initial resolution threshold and cannot be explained by a 'sorting' effect. The observations in the current study using resolution perimetry indicate that improved visual function can be demonstrated in many patients treated for early glaucoma, at least during the first 2 years of treatment.
为了确定高通分辨率视野检查能在多大程度上检测出青光眼治疗患者的任何变化，我们对56例青光眼患者和15例未经治疗的高眼压症患者进行了2至3年的随访，并对其分辨率视野检查结果进行了评估。71例受检患者中有59例在2年后与初始值相比显示出较低的分辨率阈值，即敏感性增加。治疗的青光眼患者阈值下降（中位数1.22 dB）明显大于未经治疗的高眼压症患者（0.48 dB）。未经治疗的高眼压症组的阈值下降与先前描述的学习效应相符。56例接受治疗的青光眼患者中有35例的阈值改善超过0.84 dB，这是未治疗组的置信上限，这可能表明抗青光眼治疗对这些患者有有益作用。阈值变化与初始分辨率阈值无关，也不能用“排序”效应来解释。当前使用分辨率视野检查的研究观察结果表明，许多早期青光眼治疗患者至少在治疗的前2年可以表现出视觉功能改善。
