Drance S M
Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
J Glaucoma. 1998 Aug;7(4):247-52. doi: 10.1097/00061198-199808000-00006.
The author compares the effect of betaxolol, timolol, and pilocarpine on visual functions in patients with glaucoma.
Sixty-eight patients with early glaucoma were randomly allocated to betaxolol, timolol, or pilocarpine treatment and their visual fields, motion detection, and contrast sensitivity were studied over a 24-month period. A subset of the betaxolol and timolol group were also followed with short-wave automated perimetry. One eye of each patient was used in the analysis.
All three drugs reduced pressure effectively. Pilocarpine and timolol were not significantly different from each other and both produced a more marked pressure reduction than betaxolol. There were no significant differences between the drugs on the visual fields, contrast sensitivity, or motion detection. Betaxolol appeared to have a better impact on the blue-yellow sensitivity of the upper nasal and upper temporal visual field quadrants than timolol.
In spite of a greater pressure reduction, timolol did not have a more favorable effect on visual function. In the short-wave automated perimetry, the betaxolol did marginally better than timolol. The apparent dissociation between pressure reduction and protection of visual function deserves further study.
作者比较了倍他洛尔、噻吗洛尔和毛果芸香碱对青光眼患者视觉功能的影响。
68例早期青光眼患者被随机分配接受倍他洛尔、噻吗洛尔或毛果芸香碱治疗，并在24个月期间对他们的视野、运动检测和对比敏感度进行研究。倍他洛尔组和噻吗洛尔组的一部分患者还接受了短波自动视野计检查。分析时使用每位患者的一只眼睛。
三种药物均能有效降低眼压。毛果芸香碱和噻吗洛尔之间无显著差异，且二者降低眼压的效果均比倍他洛尔更显著。在视野、对比敏感度或运动检测方面，药物之间无显著差异。倍他洛尔对上鼻侧和颞上象限视野的蓝黄敏感度的影响似乎比噻吗洛尔更好。
尽管噻吗洛尔降低眼压的幅度更大，但对视觉功能的影响并不更有利。在短波自动视野计检查中，倍他洛尔略优于噻吗洛尔。眼压降低与视觉功能保护之间明显的分离值得进一步研究。
