Colin P H
Polyclinic Courlancy, Reims, France.
Anticancer Res. 1994 Nov-Dec;14(6A):2357-61.
Combined radiotherapy and chemotherapy can be used in order to improve control and survival rates of solid tumors A concomitant radio-chemotherapy schedule optimizes interactions between chemotherapy and radiotherapy compared to a sequential approach. Experimental data try to explain these interactions at tissular, cellular or molecular levels. Cisplatin, 5 FU, mitomycin C, etoposide and hydroxyurea are particularly efficient to sensitize radiation treatment in order to obtain a supra-additive effect. Therapeutic gain without excess of toxicity should be the aim of clinical trials. This goal may have been achieved for some tumors, specially for oesophageal, rectal, pancreatic and anus cancer. For other tumors (head and neck, lung, bladder, uterine, cervix and gastric cancer) there is strong experimental and clinical support to continue this approach by clinical trials.
联合放疗和化疗可用于提高实体瘤的控制率和生存率。与序贯治疗方法相比，同步放化疗方案可优化化疗与放疗之间的相互作用。实验数据试图在组织、细胞或分子水平上解释这些相互作用。顺铂、5-氟尿嘧啶、丝裂霉素C、依托泊苷和羟基脲在使放射治疗增敏以获得超相加效应方面特别有效。无过度毒性的治疗增益应是临床试验的目标。这一目标可能已在某些肿瘤中实现，特别是食管癌、直肠癌、胰腺癌和肛门癌。对于其他肿瘤（头颈癌、肺癌、膀胱癌、子宫癌、宫颈癌和胃癌），有强有力的实验和临床证据支持通过临床试验继续采用这种方法。
