Jensen P R, Fenical W
Scripps Institution of Oceanography, La Jolla, California 92093-0236.
Annu Rev Microbiol. 1994;48:559-84. doi: 10.1146/annurev.mi.48.100194.003015.
Marine microorganisms have become an important point of study in the search for novel microbial products. Today, both academic and industrial interest in marine microorganisms is on the rise, in part because of the growing number of unique, biologically active secondary metabolites reported from marine bacteria. Our ability to assess the biosynthetic potential of marine bacteria, however, is inevitably coupled to our basic understanding of their biology. This review summarizes the chemical discoveries and biological activities reported from marine bacteria and focuses upon several microbiological topics as they relate to natural product discovery, including the distributions, diversity, and culturability of marine bacteria, as well as the role of symbiotic bacteria in the production of substances previously ascribed to other sources.
海洋微生物已成为寻找新型微生物产品的重要研究对象。如今，学术界和工业界对海洋微生物的兴趣都在上升，部分原因是从海洋细菌中报道的独特生物活性次级代谢产物的数量不断增加。然而，我们评估海洋细菌生物合成潜力的能力不可避免地与我们对其生物学的基本理解相关联。本综述总结了海洋细菌的化学发现和生物活性，并重点关注与天然产物发现相关的几个微生物学主题，包括海洋细菌的分布、多样性和可培养性，以及共生细菌在以前归因于其他来源的物质生产中的作用。
