[Importance of the time of bone marrow transplantation for demonstration of allogenic inhibition of sten cells].

The effect of the interval (4-96 hours) between the irradiation of hybrids (CBAXC57BL/6 F1 and the bone marrow transplantation from C57BL/6 mice on the manifestation of allogenic inhibition of the stem cells was studied; in the given donor-recipient model the degree of allogenic inhibition constituted 90%. The bone marrow transplantation 4 to 48 hours after the irradiation failed to influence the number of colonies in the spleen of hybrids F1, but when this transplantation was given 96 hours after the irradiation the colony-forming ability of parental hemopoietic cells regressed to 33%. Remote transplantation had no influence on the number of colonies in the spleen of syngenic recipients.