[Elimination of allogeneic inhibition and change in the differentiation of mouse bone marrow colony forming cells exposed to syngeneic lymphocytes].

A mixture of the bone marrow cells and lymphocytes of the lymph nodes of C57BL mice was injected intravenously to A X C57BL mice irradiated in a dose of 850 R. It appeared that under the effect of syngenous lymphocytes of C57BL mice the colony-forming cells (CFC) of the bone marrow of the F1 hybrid mice proliferated as if they were in the syngenous organisms. Along with the restoration of the number of CFC capable of forming colonies in a genetically foreign organism these cells, under the effect of lymphocytes, altered the direction of differentiation which was characterized by increase in the number of granulocytic colonies. This process was accompanied by the development of the blast transformation reaction and hyperplasia of the lymphoid tissue of the recipient spleen.