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[受辐照小鼠骨髓和脾脏中集落形成细胞的分布]

[Distribution of colony-forming cells in the bone marrow and spleen of irradiated mice].

作者信息

Shvets V N

出版信息

Biull Eksp Biol Med. 1976 Jul;82(7):827-9.

PMID:782610
Abstract

Two hours after the transplantation of 2-10(5) bone marrow cells 1.7--2.8% of the colony-forming units (CFU) persisted in the bone marrow and 14--16% -- in the spleen of the recipients. In 24 hours there was 1--2% of the CFU in the bone marrow and 21--26% in the spleen. The "F-factor" for these organs was constant in the recipients (under conditions of saturation) for 24 hours after the transplantation of 2.5.10(6)--1.7--10(7) bone marrow cells. The "F-factor" for the CFU seeding the spleen was 20--22% and for the CFU seeding in the femus--2,4--2,7%. It is supposed that the count of the CFU seeded in the total bone marrow volume was equal to that in the spleen. The average sum of the CFU seeding in the spleen and in the total bone marrow volume was about 40--50%. The fate of other CFU is unknown.

摘要

移植2×10⁵个骨髓细胞两小时后,受体骨髓中1.7% - 2.8%的集落形成单位(CFU)持续存在,脾脏中为14% - 16%。24小时后,骨髓中CFU占1% - 2%,脾脏中占21% - 26%。在移植2.5×10⁶ - 1.7×10⁷个骨髓细胞后,受体这些器官的“F因子”在24小时内(饱和条件下)保持恒定。脾脏中CFU的“F因子”为20% - 22%,股骨中CFU的“F因子”为2.4% - 2.7%。据推测,播种于整个骨髓体积中的CFU数量与脾脏中的相等。脾脏和整个骨髓体积中CFU播种的平均总和约为40% - 50%。其他CFU的去向未知。

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