Dorling A, Lechler R I
Department of Immunology, Royal Postgraduate Medical School, University of London, Hammersmith Hospital, UK.
Curr Opin Immunol. 1994 Oct;6(5):765-9. doi: 10.1016/0952-7915(94)90082-5.
New insights into the mechanisms of hyperacute rejection, endothelial cell activation and accommodation are clarifying the processes that determine the rejection of discordant xenografts. Recent advances include the identification of endothelial cell antigens targeted by human anti-pig antibodies and an increasing understanding of the mechanisms underlying endothelial cell activation. Novel ways to prevent hyperacute rejection, including new therapeutic agents and the use of organs from transgenic animals, are promising to significantly improve the early survival of pig organs transplanted into man. Clinical xenotransplantation has become a realizable goal.
对超急性排斥反应、内皮细胞活化及适应性调节机制的新见解，正阐明决定不协调性异种移植物排斥反应的过程。近期进展包括鉴定出人类抗猪抗体所靶向的内皮细胞抗原，以及对内皮细胞活化潜在机制的日益深入理解。预防超急性排斥反应的新方法，包括新型治疗药物及使用转基因动物的器官，有望显著提高移植到人体的猪器官的早期存活率。临床异种移植已成为一个可实现的目标。
