Igaz P
Second Department of Medicine, Semmelweis University, Faculty of Medicine, Budapest, Hungary.
Yale J Biol Med. 2001 Sep-Oct;74(5):329-40.
Due to the ever increasing shortage of suitable human donors, alternative strategies are sought to moderate the current discrepancy between the number of executable and required transplantations. Xenotransplantation (i.e., the transplantation of organs [tissues or cells] between different species) appears to be a reasonable solution. However, various problems (immunological, physiological, infectious-microbiological, ethical-juridicial) seem to be associated with xenotransplantation. One of the most formidable barriers to xenotransplantation is the phenomenon of hyperacute rejection that may lead to the destruction of the transplanted vascularized organ in a few minutes to hours. In the pathogenesis of hyperacute rejection, xenoreactive antibodies and the complement system appear to be of primary importance. Various methods can be applied to prevent hyperacute rejection; both the recipient and the donor can be treated. In this brief review, the author attempts to present a synopsis of the possible therapeutical interventions to prevent hyperacute rejection..
由于合适的人类供体日益短缺，人们正在寻求替代策略来缓解目前可进行的移植手术数量与所需移植手术数量之间的差距。异种移植（即不同物种之间的器官[组织或细胞]移植）似乎是一个合理的解决方案。然而，异种移植似乎伴随着各种问题（免疫、生理、感染微生物、伦理法律）。异种移植最可怕的障碍之一是超急性排斥反应现象，这可能在几分钟到几小时内导致移植的血管化器官被破坏。在超急性排斥反应的发病机制中，异种反应性抗体和补体系统似乎至关重要。可以采用各种方法来预防超急性排斥反应；受体和供体都可以进行治疗。在这篇简短的综述中，作者试图概述预防超急性排斥反应的可能治疗干预措施。
