We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydroxyantipyrine (4-OH AP), norantipyrine (NOR AP) and 3 hydroxymethylantipyrine (3-OHM AP) in 21 subjects. 2. The mean +/- SD of the antipyrine clearance was 2.4 +/- 1.1 h-1 (range 1.0-5.5 l h-1) and the corresponding value per kg body weight was 0.6 +/- 0.2 ml min-1 kg-1. Urinary excretion of antipyrine (AP), 4-OH AP, NOR AP and 3-OHM AP expressed as a percentage of the oral dose of antipyrine given was 2.8 +/- 2.2, 14.5 +/- 6.9, 12.3 +/- 5.6 and 7.6 +/- 3.2 respectively. 3. Compared to Africans, Saudis preferentially metabolize AP to NOR AP and compared to Caucasians to 3-OHM AP, rather than to 4-OH AP. These discrepancies may reflect age differences between the study populations rather than genetic or ethnic variations.
摘要
我们测量了18名健康沙特受试者的安替比林清除率，并测定了21名受试者中其三种代谢物的尿排泄情况：4-羟基安替比林（4-OH AP）、去甲安替比林（NOR AP）和3-羟甲基安替比林（3-OHM AP）。2. 安替比林清除率的均值±标准差为2.4±1.1 h⁻¹（范围为1.0 - 5.5 l h⁻¹），每千克体重的相应值为0.6±0.2 ml min⁻¹ kg⁻¹。安替比林（AP）、4-OH AP、NOR AP和3-OHM AP的尿排泄量以所给安替比林口服剂量的百分比表示，分别为2.8±2.2、1
